New Title

Positions: 1 postdoctoral researcher. 2 PhD Studentships (including stipend and fees)   

Project Description:  A fundamental limitation with current approaches aiming to bioprint tissues and organs is an inability to generate constructs with truly biomimetic composition and structure, resulting in the development of engineered tissues that cannot execute their specific function in vivo. This is perhaps unsurprising, as many tissues and organs continue to mature postnatally, often taking many years to attain the compositional and structural complexity that is integral to their function. A potential solution to this challenge is to engineer tissues that are more representative of an earlier stage of development, using bioprinting to not only generate such constructs, but to also provide them with guiding structures and biochemical cues that supports their maturation into fully functional tissues or organs within damaged or diseased in vivo environments. It has recently been demonstrated that such developmental processes are better recapitulated in ‘microtissues’ or ‘organoids’ formed from self-organizing (multi)cellular aggregates, motivating their use as biological building blocks for the engineering of larger scale tissues and organs. The main goal of this project is to develop a new bioprinting platform capable of spatially patterning numerous cellular aggregates or microtissues into scaled-up, personalised durable load-bearing grafts and guiding their (re)modelling into fully functional tissues in vivo within damaged or diseased environments. This will be achieved using a converged bioprinting approach capable of rapidly depositing cells and microtissues into guiding scaffold structures with high spatial resolution in a rapid, reliable, reproducible and quantifiable manner. These guiding structures will then function to direction the fusion and remodelling of cellular aggregates and microtissues into structurally organised tissues in vitro and in vivo, as well as providing medium-term (3-5 years) mechanical support to the regenerating tissue. The successful applicants will join a large consortium, working with academic and industrial partners from across Europe and New Zealand to address the goals of the project. For more information about the individual PhD and postdoctoral positions, please contact Prof. Daniel Kelly (kellyd9@tcd.ie).  

Applicant criteria:  Postdoctoral researcher: The ideal applicant will have a PhD in biomedical engineering, biomaterials, tissue engineering or a related discipline.  Previous experience in 3D (bio)printing, hydrogels, tissue engineering, cell culture, gene expression, biochemical analysis, mechanical testing, histology techniques, immunomodulatory behaviour would be highly advantageous. Excellent written and oral communication skills are essential. PhD studentships: Degree in Biomedical Engineering, Mechanical Engineering, Biomedical Sciences or a related discipline. Previous experience in biomaterials, tissue engineering, 3D (bio)printing, cell culture and/or biomechanical testing would be desirable. 

Start Date: From December 2024 onwards; positions will remain open until they are filled.   

How to apply: CVs with the names and contact details of three referees should be submitted  via email to Prof. Daniel Kelly (kellyd9@tcd.ie).   

The Kelly Lab: Dr Daniel Kelly is the Professor of Tissue Engineering at Trinity College Dublin. He is also the co-lead of the ‘Materials for Health’ platform in AMBER, the Science Foundation Ireland funded materials science centre based in Trinity College Dublin. He is a past recipient of a Science Foundation Ireland President of Ireland Young Researcher Award, a Fulbright Visiting Scholar grant (at the Department of Biomedical Engineering in Columbia University, New York) and five European Research Council awards (Starter grant 2010; Consolidator grant 2015; Proof of Concept 2017, 2023; Advanced grant 2021). His lab focuses on developing novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues. The successful applicant will join a dynamic, multidisciplinary lab consisting of 15 postdoctoral researchers and PhD students based in the Trinity Centre for Biomedical Engineering. More information can be found here: https://www.kelly-lab.com/  

About the Advanced Materials and Bioengineering Research Centre (AMBER): AMBER is a Science Foundation Ireland funded centre that provides a partnership between leading researchers in materials science and industry. More information can be found at http://ambercentre.ie/ The AMBER research centre, as a community of researchers, welcomes its responsibility to provide equal opportunities for all. We are actively seeking diversity in our research teams and particularly encourage applications from underrepresented groups. 

About the Trinity Centre for Biomedical Engineering (TCBE): TCBE is a key research centre in Trinity College combining fundamental research with translation to clinical practice. TCBE provides a structure to bring bioengineers, basic scientists and clinicians together to focus on important clinical needs and has four key research themes: Medical Devices & Advanced Drug Delivery, Neural Engineering, Biomechanics & Mechanobiology, Tissue Engineering & Regenerative Medicine. The project work will be carried out in our state-of-the-art facilities located in the Trinity Biomedical Sciences Institute.

Publications: http://scholar.google.com/citations?user=hdwHS_gAAAAJ&hl=en 

ORCID: https://orcid.org/0000-0003-4091-0992

2023:
R Burdis, X Barceló, DJ Kelly. Temporal enzymatic treatment to enhance the remodelling of multiple cartilage microtissues into a structurally organised tissue. Advanced HealthCare Materials 2023.  (https://doi.org/10.1002/adhm.202300174) 

P Gierlich, C Donohoe, K Behan, DJ Kelly, MO Senge, LC Gomes-da-Silva. Antitumor Immunity Mediated by Photodynamic Therapy Using Injectable Chitosan Hydrogels for Intratumoral and Sustained Drug Delivery. Biomacromolecules 2023. (https://doi.org/10.1021/acs.biomac.3c00591) 

F Chariyev-Prinz, N Neto, MG Monaghan, DJ Kelly. Time-Dependent Anabolic Response of hMSC-Derived Cartilage Grafts to Hydrostatic Pressure. Journal of Tissue Engineering and Regenerative Medicine 2023. (https://doi.org/10.1155/2023/9976121)

IT Whelan, R Burdis, S Shahreza, E Moeendarbary, DA Hoey, DJ Kelly. A microphysiological model of bone development and regeneration. Biofabrication 15 (3), 034103, 2023. (https://doi.org/10.1088/1758-5090/acd6be) 

Chariyev-Prinz, A Szojka, N Neto, R Burdis, MG Monaghan, DJ Kelly. An assessment of the response of human MSCs to hydrostatic pressure in environments supportive of differential chondrogenesis. Journal of Biomechanics 154, 111590, 2023. (https://doi.org/10.1016/j.jbiomech.2023.111590) 

Selcan Guler, Kian Eichholz, Farhad Chariyev-Prinz, Pierluca Pitacco, Halil Murat Aydin, Daniel J Kelly, İbrahim Vargel. Biofabrication of Poly (glycerol sebacate) Scaffolds Functionalized with a Decellularized Bone Extracellular Matrix for Bone Tissue Engineering. Bioengineering, 10, 1, 30, 2023. (https://doi.org/10.1016/j.jbiomech.2023.111590) 

B Wang, X Barceló, S Von Euw, DJ Kelly. 3D printing of mechanically functional meniscal tissue equivalents using high concentration extracellular matrix inks. Materials Today Bio 20, 100624, 2023. (https://doi.org/10.1016/j.mtbio.2023.100624) 

FE Freeman, P Dosta, LC Shanley, N Ramirez Tamez, CJ Riojas Javelly, O Mahon, DJ Kelly, N Artzi.  Localized Nanoparticle‐Mediated Delivery of miR‐29b Normalizes the Dysregulation of Bone Homeostasis Caused by Osteosarcoma whilst Simultaneously Inhibiting Tumor Growth. Advanced Materials 35 (23), 2207877, 2023. (https://doi.org/10.1002/adma.202207877) 

X Barceló, O Garcia, DJ Kelly. Chondroitinase ABC Treatment Improves the Organization and Mechanics of 3D Bioprinted Meniscal Tissue. ACS Biomaterials Science & Engineering (in press). (https://doi.org/10.1021%2Facsbiomaterials.3c00101) 

LC Shanley, OR Mahon, SA O'Rourke, NGB Neto, MG Monaghan, DJ Kelly, Dunne A. Macrophage metabolic profile is altered by hydroxyapatite particle size. Acta Biomaterialia 160, 311-321, 2023. (https://doi.org/10.1016/j.actbio.2023.01.058) 

R Burdis, GS Kronemberger, DJ Kelly. Engineering High-Quality Cartilage Microtissues Using Hydrocortisone Functionalized Microwells. Tissue Engineering Part C: Methods 29 (4), 121-133, 2023. (https://doi.org/10.1089/ten.tec.2022.0181) 

X Barceló, KF Eichholz, IF Gonçalves, O Garcia, DJ Kelly. Bioprinting of structurally organized meniscal tissue within anisotropic melt electrowritten scaffolds. Acta Biomaterialia 158, 216-227, 2023. (https://doi.org/10.1016/j.actbio.2022.12.047) 

2022:

Tanya J Levingstone, Eamon J Sheehy, Conor J Moran, Gráinne M Cunniffe, Pedro J Diaz Payno, Robert T Brady, Henrique V Almeida, Simon F Carroll, John M O’Byrne, Daniel J Kelly, Pieter AJ Brama, Fergal J O’Brien. Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model. Biomaterials and Biosystems, 8, 100066, 2022. (https://doi.org/10.1016/j.bbiosy.2022.100066)

Leandra Santos Baptista, Constance Porrini, Gabriela Soares Kronemberger, Daniel John Kelly, Cecile M Perrault. 3D organ-on-a-chip: The convergence of microphysiological systems and organoids. Frontiers in Cell and Developmental Biology 10:1043117, 2022. (https://doi.org/10.3389%2Ffcell.2022.1043117) 

Browe DC, Burdis R, Díaz-Payno PJ, Freeman FE, Nulty JM, Buckley CT, Brama PAJ, Kelly DJ. Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds. Mater Today Bio. 2022 Jul 5;16:100343. (https://doi.org/10.1016/j.mtbio.2022.100343) 

Burdis R, Chariyev-Prinz F, Browe DC, Freeman FE, Nulty J, McDonnell EE, Eichholz KF, Wang B, Brama P, Kelly DJ. Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing. Biomaterials. 2022 Aug 28;289:121750. (https://doi.org/10.1016/j.biomaterials.2022.121750) 

Kian F. Eichholz, Inês Gonçalves, Xavier Barceló, Angelica S. Federici, David A. Hoey, Daniel J. Kelly. How to design, develop and build a fully-integrated melt electrowriting 3D printer. Additive Manufacturing, Volume 58, 2022, 102998, (https://doi.org/10.1016/j.addma.2022.102998) 

Eichholz KF, Freeman FE, Pitacco P, Nulty J, Ahern D, Burdis R, Browe DC, Garcia O, Hoey DA, Kelly DJ. Scaffold microarchitecture regulates angiogenesis and the regeneration of large bone defects. Biofabrication. 2022 Aug 31;14(4). (https://doi.org/10.1088/1758-5090/ac88a1) 

Merrild NG, Holzmann V, Ariosa-Morejon Y, Faull PA, Coleman J, Barrell WB, Young G, Fischer R, Kelly DJ, Addison O, Vincent TL, Grigoriadis AE, Gentleman E. Local depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model. Acta Biomater. 2022 Sep 1;149:179-188. (https://doi.org/10.1016/j.actbio.2022.06.032) 

Pierluca Pitacco, Joanna M. Sadowska, Fergal J. O'Brien, Daniel J. Kelly. 3D bioprinting of cartilaginous templates for large bone defect healing. Acta Biomaterialia, 156, 61-74, 2023. (https://doi.org/10.1016/j.actbio.2022.07.037) 

R Paetzold, FB Coulter, G Singh, DJ Kelly, ED O'Cearbhaill. Fused filament fabrication of polycaprolactone bioscaffolds: Influence of fabrication parameters and thermal environment on geometric fidelity and mechanical properties. Bioprinting 27, e00206. (https://doi.org/10.1016/j.bprint.2022.e00206) 

Barceló, X.; Eichholz, K.F.; Garcia, O.; Kelly, D.J. Tuning the Degradation Rate of Alginate-Based Bioinks for Bioprinting Functional Cartilage Tissue. Biomedicines 2022, 10, 1621 (https://doi.org/10.3390/biomedicines10071621) 

Browe DC, Díaz-Payno PJ, Freeman FE, Schipani R, Burdis R, Ahern DP, Nulty JM, Guler S, Randall LD, Buckley CT, Brama PAJ, Kelly DJ. Bilayered extracellular matrix derived scaffolds with anisotropic pore architecture guide tissue organization during osteochondral defect repair. Acta Biomater. 2022 Apr 15;143:266-281 (https://doi.org/10.1016/j.actbio.2022.03.009) 

A Dufour, XB Gallostra, C O'Keeffe, K Eichholz, S Von Euw, O Garcia, DJ Kelly. Integrating melt electrowriting and inkjet bioprinting for engineering structurally organized articular cartilage. Biomaterials 283, 121405, 2022. (https://doi.org/10.1016/j.biomaterials.2022.121405) 

PJ Diaz-Payno, D Browe, FE Freeman, J Nulty, R Burdis, DJ Kelly. GREM1 suppresses hypertrophy of engineered cartilage in vitro but not bone formation in vivo. Tissue Engineering (in press). (https://doi.org/10.1089/ten.tea.2021.0176) 

DC Browe, PJ Díaz-Payno, FE Freeman, R Schipani, R Burdis, DP Ahern, P Brama, C.T. Buckley, DJ Kelly. Bilayered Extracellular Matrix Derived Scaffolds with Anisotropic Pore Architecture Guide Tissue Organization During Osteochondral Defect Repair. Acta Biomaterialia (in press). (https://doi.org/10.1016/j.actbio.2022.03.009) 

P Aprile, IT Whelan, BN Sathy, SF Carroll, DJ Kelly. Soft Hydrogel Environments that Facilitate Cell Spreading and Aggregation Preferentially Support Chondrogenesis of Adult Stem Cells. Macromolecular Bioscience, 2100365, 2022. (https://doi.org/10.1002/mabi.202100365) 

K Behan, A Dufour, O Garcia, D Kelly. Methacrylated Cartilage ECM-Based Hydrogels as Injectables and Bioinks for Cartilage Tissue Engineering. Biomolecules 12 (2), 216, 2022. (https://doi.org/10.3390/biom12020216) 

B Wang, F Chariyev-Prinz, R Burdis, K Eichholz, DJ Kelly. Additive manufacturing of cartilage-mimetic scaffolds as off-the-shelf implants for joint regeneration. Biofabrication 14 (2), 024101, 2022. (https://doi.org/10.1088/1758-5090/ac41a0)

2021:

R Burdis, F Chariyev-Prinz, DJ Kelly. Bioprinting of biomimetic self-organised cartilage with a supporting joint fixation device. Biofabrication 14 (1), 015008, 2021. (https://doi.org/10.1088/1758-5090/ac36be) 

Yu Shrike Zhang, Ghazaleh Haghiashtiani, Tania Hübscher, Daniel J Kelly, Jia Min Lee, Matthias Lutolf, Michael C McAlpine, Wai Yee Yeong, Marcy Zenobi-Wong, Jos Malda. 3D extrusion bioprinting. Nature Reviews Methods Primers 1 (1), 1-20, 2021. (https://doi.org/10.1038/s43586-021-00073-8) 

H Pauly, K Fischenich, D Kelly, K Popat, J Easley, RH Palmer, TL Haut Donahue. The Effect of Anterior Cruciate Ligament Reconstruction with an Electropsun Scaffold on Tibiofemoral Contact Mechanics. Annals of Biomedical Engineering, 1-12, 2021. (https://doi.org/10.1007/s10439-021-02874-0) 

FE Freeman, R Burdis, OR Mahon, DJ Kelly, N Artzi. A Spheroid Model of Early and Late‐Stage Osteosarcoma Mimicking the Divergent Relationship between Tumor Elimination and Bone Regeneration. Advanced Healthcare Materials, 2101296, 2021. (https://doi.org/10.1002/adhm.202101296) 

B Wang, PJ Díaz-Payno, DC Browe, FE Freeman, J Nulty, R Burdis, DJ Kelly. Affinity-bound growth factor within sulfated interpenetrating network bioinks for bioprinting cartilaginous tissues. Acta Biomaterialia 128, 130-142, 2021. (https://doi.org/10.1016/j.actbio.2021.04.016)

 AM McDermott, EA Eastburn, DJ Kelly, JD Boerckel. Effects of chondrogenic priming duration on mechanoregulation of engineered cartilage. Journal of Biomechanics, 110580, 2021. (https://doi.org/10.1016/j.jbiomech.2021.110580) 

J Nulty, R Burdis, DJ Kelly. Biofabrication of Prevascularised Hypertrophic Cartilage Microtissues for Bone Tissue Engineering. Frontiers in Bioengineering and Biotechnology 9, 469, 2021. (https://doi.org/10.3389/fbioe.2021.661989) 

FE Freeman, R Burdis, DJ Kelly. Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors, Trends in Molecular Medicine, 2021. (https://doi.org/10.1016/j.molmed.2021.05.001) 

I Whelan, E Moeendarbary, D Hoey, DJ Kelly. Biofabrication of vasculature in microphysiological models of bone. Biofabrication, 13, 032004, 2021. (https://doi.org/10.1088/1758-5090/ac04f7)

OR Mahon, DC Browe, PJ Diaz-Payno, P Pitacco, KT Cunningham, A Dunne, DJ Kelly. Extracellular matrix scaffolds derived from different musculoskeletal tissues drive distinct macrophage phenotypes and direct tissue-specific cellular differentiation. Journal of Immunology and Regenerative Medicine 12, 100041, 2021. (https://doi.org/10.1016%2Fj.bioactmat.2024.01.004) 

J Nulty, FE Freeman, DC Browe, R Burdis, DP Ahern, P Pitacco, YB Lee, E Alsberg, DJ Kelly. 3D bioprinting of prevascularised implants for the repair of critically-sized bone defects. Acta Biomaterialia 126, 154-169, 2021. (https://doi.org/10.1016/j.actbio.2021.03.003) 

R Burdis, DJ Kelly. Biofabrication and bioprinting using cellular aggregates, microtissues and organoids for the engineering of musculoskeletal tissues. Acta Biomaterialia 126, 1-14, 2021. (https://doi.org/10.1016/j.actbio.2021.03.016) 

JM Sadowska, KJ Genoud, DJ Kelly, FJ O'Brien. Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue. Materials Today, 46, 136-154, 2021. (http://dx.doi.org/10.1016/j.mattod.2020.12.018) 

LC Shanley, OR Mahon, DJ Kelly, A Dunne. Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages. Acta Biomaterialia , 133, 208-221, 2021. (https://doi.org/10.1016/j.actbio.2021.02.023)  

SF Carroll, CT Buckley, DJ Kelly. Measuring and Modeling Oxygen Transport and Consumption in 3D Hydrogels Containing Chondrocytes and Stem Cells of Different Tissue Origins. Frontiers in Bioengineering and Biotechnology, 9: 591126, 2021. (https://doi.org/10.3389/fbioe.2021.591126) 

R Sridharan, DJ Kelly, FJ O'Brien. Substrate Stiffness Modulates the Crosstalk Between Mesenchymal Stem Cells and Macrophages. Journal of Biomechanical Engineering 143 (3), 2021. (https://doi.org/10.1115/1.4048809)

2020:

Aprile, P., Kelly, DJ. Hydrostatic pressure regulates the volume, aggregation and chondrogenic differentiation of bone marrow derived stromal cells Frontiers in Bioengineering and Biotechnology 8, 1526, 2020. (https://doi.org/10.3389/fbioe.2020.619914) 

KF Eichholz, S Von Euw, R Burdis, DJ Kelly, DA Hoey. Development of a New Bone‐Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating. Advanced Healthcare Materials, 2001102, 2020. (https://doi.org/10.1002/adhm.202001102) 

R Sridharan, KJ Genoud, DJ Kelly, FJ O’Brien. Hydroxyapatite Particle Shape and Size Influence MSC Osteogenesis by Directing the Macrophage Phenotype in Collagen-Hydroxyapatite Scaffolds. ACS Applied Bio Materials 3 (11), 7562-7574, 2020. (https://doi.org/10.1021/acsabm.0c00801) 

Pedro J Gouveia, Tom Hodgkinson, Isabel Amado, Joanna M Sadowska, Alan J Ryan, Sara Romanazzo, Simon Carroll, Sally-Ann Cryan, Daniel J Kelly, Fergal J O'Brien. Development of collagen-poly (caprolactone)-based core-shell scaffolds supplemented with proteoglycans and glycosaminoglycans for ligament repair. Materials Science and Engineering: C , 111657, 2020. (https://doi.org/10.1016/j.msec.2020.111657)  

Freeman, F., Pitacco, P., van Dommelen, L., Nulty, J., Browe, D.C., Shin, J-Y., Alsberg, E., Kelly, D.J. 3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration. Sciences Advances, 6 (33), eabb5093, 2020. (https://doi.org/10.1126/sciadv.abb5093)

M Lemoine, SM Casey, JM O'Byrne, DJ Kelly, FJ O'Brien. The development of natural polymer scaffold-based therapeutics for osteochondral repair. Biochemical Society Transactions 48 (4), 1433-1445. (https://doi.org/10.1042/bst20190938) 

Stanislas Von Euw, Thierry Azaïs, Viacheslav Manichev, Guillaume Laurent, Gérard Pehau-Arnaudet, Margarita Rivers, Nagarajan Murali, Daniel J Kelly, Paul G Falkowski. Solid-state phase transformation and self-assembly of amorphous nanoparticles into higher-order mineral structures. Journal of the American Chemical Society 142 (29), 12811-12825, 2020. (https://doi.org/10.1021/jacs.5b07931) 

Olvera, D., Sathy, B., Kelly, D.J. Spatial presentation of tissue-specific extracellular matrix components along electrospun scaffolds for tissue engineering the bone-ligament interface. ACS Biomaterials Science & Engineering, 6 (9), 5145-5161, 2020. (https://doi.org/10.1021/acsbiomaterials.0c00337) 

Critchley, S. Sheehy, E.J., Cunniffe, G., Diaz-Payno, Carroll, S., Oju, J., Eben., A., Brama, P., Kelly, D.J. 3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects. Acta Biomaterilia, 113, 130-143, 2020. (https://doi.org/10.1016/j.actbio.2020.05.040) 

P.J. Diaz-Payno, D.C. Browe, G.M. Cunniffe, Daniel J. Kelly. The identification of articular cartilage and growth plate extracellular matrix-specific proteins supportive of either osteogenesis or stable chondrogenesis of stem cells. Biochemical and Biophysical Research Communications, 528 (2), 285-291, 2020. (https://doi.org/10.1016/j.bbrc.2020.05.074) 

Schipani R, Scheurer S, Florentin R, Critchley SE, Kelly DJ. Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites. Biofabrication. 12;12(3):035011, 2020. (https://doi.org/10.1088/1758-5090/ab8708) 

Freeman, F.E., Brennan, M.Á., Browe, D.C., Kelly, D.J. McNamara, L.M., Layrolle, P.A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect. Frontiers in Bioengineering and Biotechnology 8,230, 2020. (https://doi.org/10.3389/fbioe.2020.00230) 

Westin, C.B., Nagahara, M.H.T., Decarli, M.C., Kelly, D.J., Moraes, Â.M. Development and characterization of carbohydrate-based thermosensitive hydrogels for cartilage tissue engineering. European Polymer Journal, 129,109637, 2020. (https://doi.org/10.3390%2Fpolym13234199) 

Olwyn R Mahon, David C Browe, Tomas Gonzalez-Fernandez, Pierluca Pitacco, Ian T Whelan, Stanislas Von Euw, Christopher Hobbs, Valeria Nicolosi, Kyle T Cunningham, Kingston HG Mills, Daniel J Kelly, Aisling Dunne. Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner. Biomaterials 239, 119833, 2020. R Schipani, D Nolan, C Lally, DJ Kelly. Integrating Finite Element Modelling and 3D Printing to Engineer Biomimetic Polymeric Scaffolds for Tissue Engineering. Connective Tissue Research 61(2):174-189, 2020. (https://doi.org/10.1080/03008207.2019.1656720)

R Schipani, D Nolan, C Lally, DJ Kelly. Integrating Finite Element Modelling and 3D Printing to Engineer Biomimetic Polymeric Scaffolds for Tissue Engineering. Connective Tissue Research 61(2):174-189, 2020. (https://doi.org/10.1080/03008207.2019.1656720)

2019:

F Freeman, D Browe, J Nulty, S Von Euw, W Grayson, DJ Kelly. Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering. e Cells and Materials, 38, 168-187, 2019. (https://doi.org/10.22203/ecm.v038a12) 

AM McDermott, S Herberg, DE Mason, JM Collins, HB Pearson, JH Dawahare, R Tang, AN Patwa, MW Grinstaff, DJ Kelly, E Alsberg, JD Boerckel. Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration. Science translational medicine 11 (495), eaav7756, 2019. (https://doi.org/10.1126/scitranslmed.aav7756)

 OR Mahon, DJ Kelly, GM McCarthy, A Dunne. Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization. Osteoarthritis and cartilage (in press). (https://doi.org/10.1016/j.joca.2019.10.010) 

EJ Sheehy, DJ Kelly, FJ O’Brien. Biomaterial-based endochondral bone regeneration: A shift from traditional tissue engineering paradigms to developmentally inspired strategies. Materials Today Bio, 100009, 2019. (https://doi.org/10.1016/j.mtbio.2019.100009) 

DC Browe, OR Mahon, PJ Díaz‐Payno, N Cassidy, I Dudurych, A Dunne, DJ Kelly. Glyoxal cross‐linking of solubilised extracellular matrix to produce highly porous, elastic and chondro‐permissive scaffolds for orthopaedic tissue engineering. Journal of Biomedical Materials Research Part A, 107(10):2222-2234, 2019. (https://doi.org/10.1002/jbm.a.36731) 

Gonzalez-Fernandez T., Rathan S., Hobbs C., Pitacco P., Freeman F.E., Cunniffe G.M., Dunne N.J., McCarthy H., Nicolosi V., O’Brien F.J., Kelly D.J Pore-Forming Bioinks to Enable Spatio-Temporally Defined Gene Delivery in Bioprinted Tissues. Journal of Controlled Release 301, 13-27, 2019. (https://doi.org/10.1016/j.jconrel.2019.03.006) 

Sridharan, R., Cavanagh, B., Cameron, A., Kelly, D.J. O’Brien, F.J. Material stiffness influences the polarization state, function and migration of macrophages. Acta Biomaterilia 15;89:47-59, 2019. (https://doi.org/10.1016/j.actbio.2019.02.048) 

Olvera, D., Schipani, R., Sathy, B., Kelly, D.J. Electrospinning of highly porous yet mechanically functional microfibrillar scaffolds at the human scale for ligament and tendon tissue engineering. Biomedical Materials 14 (3), 035016, 2019. (https://doi.org/10.1088/1748-605x/ab0de1) 

Sathy, B.N., Daly, A., Olvera, D., Fernandez, T.G., Cunniffe, G., Pentlavalli, S., Chambers, P., Dunne, N. McCarthy, H.O., Jeon, O., Alsberg, E., Donahue, T.H., Kelly, D.J. Hypoxia Mimicking Hydrogels to Regulate the Fate of Transplanted Stem Cells. Acta Biomaterilia 88, 314-324, 2019. (https://doi.org/10.1016/j.actbio.2019.02.042) 

Daly, A., Kelly, D.J. Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers. Biomaterials 197, 194-206, 2019. (https://doi.org/10.1016/j.biomaterials.2018.12.028) 

Rathan, S., Dejob, L., Schipani, R., Haffner, B., Möbius, M.E., Kelly, D.J Fiber Reinforced Cartilage ECM Functionalized Bioinks for Functional Cartilage Tissue Engineering. Advanced Healthcare Materials 8 (7), 1801501, 2019. (https://doi.org/10.1002/adhm.201801501)  

Pauly, H., Kelly, D.J., Popat, K., Palmer, R., Haut Donahue, T.L Mechanical properties of a hierarchical electrospun scaffold for ovine anterior cruciate ligament replacement. Journal of Orthopaedic Research 37 (2), 421-430, 2019. (https://doi.org/10.1002/jor.24183) 

Sridharan, R., Ryan, E.J., Kearney, C.J., Kelly, D.J., O’Brien, F.J. Macrophage Polarization in Response to Collagen Scaffold Stiffness Is Dependent on Cross-Linking Agent Used To Modulate the Stiffness. ACS Biomater. Sci. Eng. 5 (2), 544-552, 2018. (https://doi.org/10.1021/acsbiomaterials.8b00910) 

Cunniffe, G.M., Díaz-Payno, P.J. Sheehy, E.J. Critchley, S.E., Almeida, H.V., Pitacco, P., Simon F. Carroll, S.F., Mahon, O.R., Dunne, A., Levingstone, T.J., Moran, C.J., Brady, R.T., O’Brien, F.J., Brama, P., Kelly, D.J. Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues. Biomaterials 188, 63-73, 2019. (https://doi.org/10.1016%2Fj.mtbio.2022.100343) 

Critchley, S., Cunniffe, G.M., O’Reilly, A., Diaz-Payno, P.J., Schipani, R., McAlinden, A., Withers, D., Shin, J.Y., Alsberg, E., Kelly, D.J Regeneration of osteochondral defects using developmentally inspired cartilaginous templates. Tissue Engineering Part A 25 (3-4), 159-171, 2019. (https://doi.org/10.1089/ten.tea.2018.0046)