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ABOUT US
The goal of the Kelly Lab is to develop novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues such as articular cartilage, meniscus and bone. Professor Daniel Kelly holds the Chair of Tissue Engineering at Trinity College Dublin (TCD). He is the recipient of five European Research Council awards (Starter grant 2010; Consolidator grant 2015; Proof of Concept grant 2017, 2023; Advanced grant 2021), which have led to the development of new single stage strategies for bone and cartilage repair and pioneering innovations in 3D (bio)printing for the regeneration of musculoskeletal tissues. He was elected a fellow of Trinity College Dublin in 2010 and was promoted to his current chair in 2017. Notable recognitions of Prof Kelly’s academic work include being awarded the 2012 Perren Award by the European Society of Biomechanics, the Science Foundation Ireland Industry Partnership Award in 2019, the Silver Medal of Royal Academy of Medicine in Ireland (Bioengineering Section) in 2022 and the mid-term career award from the Tissue Engineering and Regenerative Medicine International (TERMIS) EU society in 2023. Prof Kelly is also one of the founding Principal Investigators of the Advanced Materials and Bioengineering Research (AMBER) centre, a Science Foundation Ireland funded centre that links leading researchers in materials science and bioengineering with industry (https://ambercentre.ie/).

Cartilage Tissue Engineering

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Bone & osteochondral tissue engineering

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Extracellular matrix derived scaffolds for bone & joint repair

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3D (bio)printing of musculoskeletal tissues

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Gabriela Soares Kronemberger

Postdoctoral Researcher

Bio fabrication of musculoskeletal tissues by using microtissues as biological building blocks

Tosca Roncada

Postdoctoral Researcher

Utilizing decellularized extracellular matrix to engineer cartilage and meniscus tissues, with a particular emphasis on directing the organization of new tissue growth

Sinead O'Rourke

Postdoctoral Researcher

Characterisation of the immune response to novel biomaterials for enhanced regeneration of musculoskeletal tissue

Josephine Wu

Postdoctoral Researcher

3D bio printing of spatiotemporal cues for cell spheroid-based cartilage tissue engineering

Rory Gibney

Postdoctoral Researcher

Melt electro-writing(MEW) of scaffold for the repair of an osteochondral defect facilitated by decellularlised extracellular matrix (dECM)

Lianne Shanley

PhD Candidate

Characterisation and modulation of the immune response to biomaterials for bone tissue engineering

Nadia Rodriguez

PhD Candidate

Biofabrication of Zonally Defined Articular Cartilage Grafts

Kyle Storey

PhD Candidate

Development of a high cell density bio printing platform that utilizes 4D boundaries to engineer highly organized, an isotropic soft tissue

Francesca Spagnuolo

PhD Candidate

Development of a novel bio printing platform for extrusion bio printing of microtissues/cellular aggregates for musculoskeletal tissue engineering

Giovanni Gonnella

PhD Candidate

3D printed off-the-shelf extracellular-matrix derived scaffolds for osteochondral defect repair

Kaoutar Chattahy

PhD Candidate

3D Bioprinting Microtissues as Building Blocks to Engineer Anisotropic Meniscal Grafts.

Aliaa Karam

PhD Candidate

3D Bio printing of Structurally Organized Articular Cartilage and Osteochondral Grafts using High Cell Density Bio inks for Biological Joint Resurfacing

Catarina Correia

PhD Candidate

3D printing of structurally anisotropic and mechanically functional tissues by guiding the fusion of stem cell derived cartilage microtissues

Rosario Milazzo

PhD Candidate

Development of cartilage and synovium models on-a-chip

Bahar Tavakkoli

Lab manager

Marcin Kotlarz

Postdoctoral Researcher

Development of a biological implants for the treatment of diseased joints and osteochondral defects

Professor Daniel Kelly from Trinity College Dublin is elected as a new member of the Royal Irish Academy

Professor Daniel Kelly from Trinity College Dublin is elected as a new member of the Royal Irish Academy

28 newly elected Members were officially admitted to the Academy on 21 May 2024, for their exceptional contributions to the sciences, humanities and social sciences, as well as to public service. https://www.ria.ie/news/membership/admittance-day-2024

Our labs work is highlighted in a recent news article in the Irish Times

Our labs work is highlighted in a recent news article in the Irish Times

https://www.irishtimes.com/science/2024/02/22/aim-of-next-generation-biomaterials-is-to-train-human-tissue-to-heal-itself/?s=09

Advanced Healthcare Materials

Advanced Healthcare Materials

Learn more: https://x.com/AdvSciNews/status/1752708547480092894?s=20

Congratulations to Dr Josephine Wu and Nadia Rodriguez for presenting their work at the 12th World Biomaterials Congress, 26-31 May 2024, Daegu, South Korea.

Congratulations to Dr Josephine Wu and Nadia Rodriguez for presenting their work at the 12th World Biomaterials Congress, 26-31 May 2024, Daegu, South Korea.

Best Poster award by Francesca Spagnuolo in Alpine winter school for biofabrication 2024, Radstadt, Austria (10-13th January).

Best Poster award by Francesca Spagnuolo in Alpine winter school for biofabrication 2024, Radstadt, Austria (10-13th January).

Kyle Storey Presented at the Cellink Partnership Conference 2023 in the Rising Pioneers in Bioprinting Special Session.

Kyle Storey Presented at the Cellink Partnership Conference 2023 in the Rising Pioneers in Bioprinting Special Session.

Tweets from @dannykelly1978

  • Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute Trinity College, 152-160 Pearse Street Dublin 2, Ireland. D02 R590
  •  Mon-Fri - 09:00-17:00
Vacancies
Join our lab! We are always interested in expanding our research group. If you are interested in applying for funding through the Irish Research Council (www.research.ie), Science Foundation Ireland  (www.sfi.ie) or Marie Curie programmes (https://marie-sklodowska-curie-actions.ec.europa.eu/) please contact me directly (KELLYD9@tcd.ie) to discuss.

Publications: http://scholar.google.com/citations?user=hdwHS_gAAAAJ&hl=en 

ORCID: https://orcid.org/0000-0003-4091-0992

2023:
R Burdis, X Barceló, DJ Kelly. Temporal enzymatic treatment to enhance the remodelling of multiple cartilage microtissues into a structurally organised tissue. Advanced HealthCare Materials 2023.  (https://doi.org/10.1002/adhm.202300174

P Gierlich, C Donohoe, K Behan, DJ Kelly, MO Senge, LC Gomes-da-Silva. Antitumor Immunity Mediated by Photodynamic Therapy Using Injectable Chitosan Hydrogels for Intratumoral and Sustained Drug Delivery. Biomacromolecules 2023. (https://doi.org/10.1021/acs.biomac.3c00591

F Chariyev-Prinz, N Neto, MG Monaghan, DJ Kelly. Time-Dependent Anabolic Response of hMSC-Derived Cartilage Grafts to Hydrostatic Pressure. Journal of Tissue Engineering and Regenerative Medicine 2023. (https://doi.org/10.1155/2023/9976121)

IT Whelan, R Burdis, S Shahreza, E Moeendarbary, DA Hoey, DJ Kelly. A microphysiological model of bone development and regeneration. Biofabrication 15 (3), 034103, 2023. (https://doi.org/10.1088/1758-5090/acd6be

Chariyev-Prinz, A Szojka, N Neto, R Burdis, MG Monaghan, DJ Kelly. An assessment of the response of human MSCs to hydrostatic pressure in environments supportive of differential chondrogenesis. Journal of Biomechanics 154, 111590, 2023. (https://doi.org/10.1016/j.jbiomech.2023.111590

Selcan Guler, Kian Eichholz, Farhad Chariyev-Prinz, Pierluca Pitacco, Halil Murat Aydin, Daniel J Kelly, İbrahim Vargel. Biofabrication of Poly (glycerol sebacate) Scaffolds Functionalized with a Decellularized Bone Extracellular Matrix for Bone Tissue Engineering. Bioengineering, 10, 1, 30, 2023. (https://doi.org/10.1016/j.jbiomech.2023.111590

B Wang, X Barceló, S Von Euw, DJ Kelly. 3D printing of mechanically functional meniscal tissue equivalents using high concentration extracellular matrix inks. Materials Today Bio 20, 100624, 2023. (https://doi.org/10.1016/j.mtbio.2023.100624

FE Freeman, P Dosta, LC Shanley, N Ramirez Tamez, CJ Riojas Javelly, O Mahon, DJ Kelly, N Artzi.  Localized Nanoparticle‐Mediated Delivery of miR‐29b Normalizes the Dysregulation of Bone Homeostasis Caused by Osteosarcoma whilst Simultaneously Inhibiting Tumor Growth. Advanced Materials 35 (23), 2207877, 2023. (https://doi.org/10.1002/adma.202207877

X Barceló, O Garcia, DJ Kelly. Chondroitinase ABC Treatment Improves the Organization and Mechanics of 3D Bioprinted Meniscal Tissue. ACS Biomaterials Science & Engineering (in press). (https://doi.org/10.1021%2Facsbiomaterials.3c00101

LC Shanley, OR Mahon, SA O'Rourke, NGB Neto, MG Monaghan, DJ Kelly, Dunne A. Macrophage metabolic profile is altered by hydroxyapatite particle size. Acta Biomaterialia 160, 311-321, 2023. (https://doi.org/10.1016/j.actbio.2023.01.058

R Burdis, GS Kronemberger, DJ Kelly. Engineering High-Quality Cartilage Microtissues Using Hydrocortisone Functionalized Microwells. Tissue Engineering Part C: Methods 29 (4), 121-133, 2023. (https://doi.org/10.1089/ten.tec.2022.0181

X Barceló, KF Eichholz, IF Gonçalves, O Garcia, DJ Kelly. Bioprinting of structurally organized meniscal tissue within anisotropic melt electrowritten scaffolds. Acta Biomaterialia 158, 216-227, 2023. (https://doi.org/10.1016/j.actbio.2022.12.047

2022:

Tanya J Levingstone, Eamon J Sheehy, Conor J Moran, Gráinne M Cunniffe, Pedro J Diaz Payno, Robert T Brady, Henrique V Almeida, Simon F Carroll, John M O’Byrne, Daniel J Kelly, Pieter AJ Brama, Fergal J O’Brien. Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model. Biomaterials and Biosystems, 8, 100066, 2022. (https://doi.org/10.1016/j.bbiosy.2022.100066)

Leandra Santos Baptista, Constance Porrini, Gabriela Soares Kronemberger, Daniel John Kelly, Cecile M Perrault. 3D organ-on-a-chip: The convergence of microphysiological systems and organoids. Frontiers in Cell and Developmental Biology 10:1043117, 2022. (https://doi.org/10.3389%2Ffcell.2022.1043117

Browe DC, Burdis R, Díaz-Payno PJ, Freeman FE, Nulty JM, Buckley CT, Brama PAJ, Kelly DJ. Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds. Mater Today Bio. 2022 Jul 5;16:100343. (https://doi.org/10.1016/j.mtbio.2022.100343

Burdis R, Chariyev-Prinz F, Browe DC, Freeman FE, Nulty J, McDonnell EE, Eichholz KF, Wang B, Brama P, Kelly DJ. Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing. Biomaterials. 2022 Aug 28;289:121750. (https://doi.org/10.1016/j.biomaterials.2022.121750

Kian F. Eichholz, Inês Gonçalves, Xavier Barceló, Angelica S. Federici, David A. Hoey, Daniel J. Kelly. How to design, develop and build a fully-integrated melt electrowriting 3D printer. Additive Manufacturing, Volume 58, 2022, 102998, (https://doi.org/10.1016/j.addma.2022.102998

Eichholz KF, Freeman FE, Pitacco P, Nulty J, Ahern D, Burdis R, Browe DC, Garcia O, Hoey DA, Kelly DJ. Scaffold microarchitecture regulates angiogenesis and the regeneration of large bone defects. Biofabrication. 2022 Aug 31;14(4). (https://doi.org/10.1088/1758-5090/ac88a1

Merrild NG, Holzmann V, Ariosa-Morejon Y, Faull PA, Coleman J, Barrell WB, Young G, Fischer R, Kelly DJ, Addison O, Vincent TL, Grigoriadis AE, Gentleman E. Local depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model. Acta Biomater. 2022 Sep 1;149:179-188. (https://doi.org/10.1016/j.actbio.2022.06.032

Pierluca Pitacco, Joanna M. Sadowska, Fergal J. O'Brien, Daniel J. Kelly. 3D bioprinting of cartilaginous templates for large bone defect healing. Acta Biomaterialia, 156, 61-74, 2023. (https://doi.org/10.1016/j.actbio.2022.07.037

R Paetzold, FB Coulter, G Singh, DJ Kelly, ED O'Cearbhaill. Fused filament fabrication of polycaprolactone bioscaffolds: Influence of fabrication parameters and thermal environment on geometric fidelity and mechanical properties. Bioprinting 27, e00206. (https://doi.org/10.1016/j.bprint.2022.e00206

Barceló, X.; Eichholz, K.F.; Garcia, O.; Kelly, D.J. Tuning the Degradation Rate of Alginate-Based Bioinks for Bioprinting Functional Cartilage Tissue. Biomedicines 2022, 10, 1621 (https://doi.org/10.3390/biomedicines10071621

Browe DC, Díaz-Payno PJ, Freeman FE, Schipani R, Burdis R, Ahern DP, Nulty JM, Guler S, Randall LD, Buckley CT, Brama PAJ, Kelly DJ. Bilayered extracellular matrix derived scaffolds with anisotropic pore architecture guide tissue organization during osteochondral defect repair. Acta Biomater. 2022 Apr 15;143:266-281 (https://doi.org/10.1016/j.actbio.2022.03.009

A Dufour, XB Gallostra, C O'Keeffe, K Eichholz, S Von Euw, O Garcia, DJ Kelly. Integrating melt electrowriting and inkjet bioprinting for engineering structurally organized articular cartilage. Biomaterials 283, 121405, 2022. (https://doi.org/10.1016/j.biomaterials.2022.121405

PJ Diaz-Payno, D Browe, FE Freeman, J Nulty, R Burdis, DJ Kelly. GREM1 suppresses hypertrophy of engineered cartilage in vitro but not bone formation in vivo. Tissue Engineering (in press). (https://doi.org/10.1089/ten.tea.2021.0176

DC Browe, PJ Díaz-Payno, FE Freeman, R Schipani, R Burdis, DP Ahern, P Brama, C.T. Buckley, DJ Kelly. Bilayered Extracellular Matrix Derived Scaffolds with Anisotropic Pore Architecture Guide Tissue Organization During Osteochondral Defect Repair. Acta Biomaterialia (in press). (https://doi.org/10.1016/j.actbio.2022.03.009

P Aprile, IT Whelan, BN Sathy, SF Carroll, DJ Kelly. Soft Hydrogel Environments that Facilitate Cell Spreading and Aggregation Preferentially Support Chondrogenesis of Adult Stem Cells. Macromolecular Bioscience, 2100365, 2022. (https://doi.org/10.1002/mabi.202100365

K Behan, A Dufour, O Garcia, D Kelly. Methacrylated Cartilage ECM-Based Hydrogels as Injectables and Bioinks for Cartilage Tissue Engineering. Biomolecules 12 (2), 216, 2022. (https://doi.org/10.3390/biom12020216

B Wang, F Chariyev-Prinz, R Burdis, K Eichholz, DJ Kelly. Additive manufacturing of cartilage-mimetic scaffolds as off-the-shelf implants for joint regeneration. Biofabrication 14 (2), 024101, 2022. (https://doi.org/10.1088/1758-5090/ac41a0)

2021:

R Burdis, F Chariyev-Prinz, DJ Kelly. Bioprinting of biomimetic self-organised cartilage with a supporting joint fixation device. Biofabrication 14 (1), 015008, 2021. (https://doi.org/10.1088/1758-5090/ac36be

Yu Shrike Zhang, Ghazaleh Haghiashtiani, Tania Hübscher, Daniel J Kelly, Jia Min Lee, Matthias Lutolf, Michael C McAlpine, Wai Yee Yeong, Marcy Zenobi-Wong, Jos Malda. 3D extrusion bioprinting. Nature Reviews Methods Primers 1 (1), 1-20, 2021. (https://doi.org/10.1038/s43586-021-00073-8

H Pauly, K Fischenich, D Kelly, K Popat, J Easley, RH Palmer, TL Haut Donahue. The Effect of Anterior Cruciate Ligament Reconstruction with an Electropsun Scaffold on Tibiofemoral Contact Mechanics. Annals of Biomedical Engineering, 1-12, 2021. (https://doi.org/10.1007/s10439-021-02874-0

FE Freeman, R Burdis, OR Mahon, DJ Kelly, N Artzi. A Spheroid Model of Early and Late‐Stage Osteosarcoma Mimicking the Divergent Relationship between Tumor Elimination and Bone Regeneration. Advanced Healthcare Materials, 2101296, 2021. (https://doi.org/10.1002/adhm.202101296

B Wang, PJ Díaz-Payno, DC Browe, FE Freeman, J Nulty, R Burdis, DJ Kelly. Affinity-bound growth factor within sulfated interpenetrating network bioinks for bioprinting cartilaginous tissues. Acta Biomaterialia 128, 130-142, 2021. (https://doi.org/10.1016/j.actbio.2021.04.016)

 AM McDermott, EA Eastburn, DJ Kelly, JD Boerckel. Effects of chondrogenic priming duration on mechanoregulation of engineered cartilage. Journal of Biomechanics, 110580, 2021. (https://doi.org/10.1016/j.jbiomech.2021.110580

J Nulty, R Burdis, DJ Kelly. Biofabrication of Prevascularised Hypertrophic Cartilage Microtissues for Bone Tissue Engineering. Frontiers in Bioengineering and Biotechnology 9, 469, 2021. (https://doi.org/10.3389/fbioe.2021.661989

FE Freeman, R Burdis, DJ Kelly. Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors, Trends in Molecular Medicine, 2021. (https://doi.org/10.1016/j.molmed.2021.05.001

I Whelan, E Moeendarbary, D Hoey, DJ Kelly. Biofabrication of vasculature in microphysiological models of bone. Biofabrication, 13, 032004, 2021. (https://doi.org/10.1088/1758-5090/ac04f7)

OR Mahon, DC Browe, PJ Diaz-Payno, P Pitacco, KT Cunningham, A Dunne, DJ Kelly. Extracellular matrix scaffolds derived from different musculoskeletal tissues drive distinct macrophage phenotypes and direct tissue-specific cellular differentiation. Journal of Immunology and Regenerative Medicine 12, 100041, 2021. (https://doi.org/10.1016%2Fj.bioactmat.2024.01.004

J Nulty, FE Freeman, DC Browe, R Burdis, DP Ahern, P Pitacco, YB Lee, E Alsberg, DJ Kelly. 3D bioprinting of prevascularised implants for the repair of critically-sized bone defects. Acta Biomaterialia 126, 154-169, 2021. (https://doi.org/10.1016/j.actbio.2021.03.003

R Burdis, DJ Kelly. Biofabrication and bioprinting using cellular aggregates, microtissues and organoids for the engineering of musculoskeletal tissues. Acta Biomaterialia 126, 1-14, 2021. (https://doi.org/10.1016/j.actbio.2021.03.016

JM Sadowska, KJ Genoud, DJ Kelly, FJ O'Brien. Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue. Materials Today, 46, 136-154, 2021. (http://dx.doi.org/10.1016/j.mattod.2020.12.018

LC Shanley, OR Mahon, DJ Kelly, A Dunne. Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages. Acta Biomaterialia , 133, 208-221, 2021. (https://doi.org/10.1016/j.actbio.2021.02.023)  

SF Carroll, CT Buckley, DJ Kelly. Measuring and Modeling Oxygen Transport and Consumption in 3D Hydrogels Containing Chondrocytes and Stem Cells of Different Tissue Origins. Frontiers in Bioengineering and Biotechnology, 9: 591126, 2021. (https://doi.org/10.3389/fbioe.2021.591126

R Sridharan, DJ Kelly, FJ O'Brien. Substrate Stiffness Modulates the Crosstalk Between Mesenchymal Stem Cells and Macrophages. Journal of Biomechanical Engineering 143 (3), 2021. (https://doi.org/10.1115/1.4048809)

2020:

Aprile, P., Kelly, DJ. Hydrostatic pressure regulates the volume, aggregation and chondrogenic differentiation of bone marrow derived stromal cells Frontiers in Bioengineering and Biotechnology 8, 1526, 2020. (https://doi.org/10.3389/fbioe.2020.619914

KF Eichholz, S Von Euw, R Burdis, DJ Kelly, DA Hoey. Development of a New Bone‐Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating. Advanced Healthcare Materials, 2001102, 2020. (https://doi.org/10.1002/adhm.202001102

R Sridharan, KJ Genoud, DJ Kelly, FJ O’Brien. Hydroxyapatite Particle Shape and Size Influence MSC Osteogenesis by Directing the Macrophage Phenotype in Collagen-Hydroxyapatite Scaffolds. ACS Applied Bio Materials 3 (11), 7562-7574, 2020. (https://doi.org/10.1021/acsabm.0c00801

Pedro J Gouveia, Tom Hodgkinson, Isabel Amado, Joanna M Sadowska, Alan J Ryan, Sara Romanazzo, Simon Carroll, Sally-Ann Cryan, Daniel J Kelly, Fergal J O'Brien. Development of collagen-poly (caprolactone)-based core-shell scaffolds supplemented with proteoglycans and glycosaminoglycans for ligament repair. Materials Science and Engineering: C , 111657, 2020. (https://doi.org/10.1016/j.msec.2020.111657)  

Freeman, F., Pitacco, P., van Dommelen, L., Nulty, J., Browe, D.C., Shin, J-Y., Alsberg, E., Kelly, D.J. 3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration. Sciences Advances, 6 (33), eabb5093, 2020. (https://doi.org/10.1126/sciadv.abb5093)

M Lemoine, SM Casey, JM O'Byrne, DJ Kelly, FJ O'Brien. The development of natural polymer scaffold-based therapeutics for osteochondral repair. Biochemical Society Transactions 48 (4), 1433-1445. (https://doi.org/10.1042/bst20190938

Stanislas Von Euw, Thierry Azaïs, Viacheslav Manichev, Guillaume Laurent, Gérard Pehau-Arnaudet, Margarita Rivers, Nagarajan Murali, Daniel J Kelly, Paul G Falkowski. Solid-state phase transformation and self-assembly of amorphous nanoparticles into higher-order mineral structures. Journal of the American Chemical Society 142 (29), 12811-12825, 2020. (https://doi.org/10.1021/jacs.5b07931

Olvera, D., Sathy, B., Kelly, D.J. Spatial presentation of tissue-specific extracellular matrix components along electrospun scaffolds for tissue engineering the bone-ligament interface. ACS Biomaterials Science & Engineering, 6 (9), 5145-5161, 2020. (https://doi.org/10.1021/acsbiomaterials.0c00337

Critchley, S. Sheehy, E.J., Cunniffe, G., Diaz-Payno, Carroll, S., Oju, J., Eben., A., Brama, P., Kelly, D.J. 3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects. Acta Biomaterilia, 113, 130-143, 2020. (https://doi.org/10.1016/j.actbio.2020.05.040

P.J. Diaz-Payno, D.C. Browe, G.M. Cunniffe, Daniel J. Kelly. The identification of articular cartilage and growth plate extracellular matrix-specific proteins supportive of either osteogenesis or stable chondrogenesis of stem cells. Biochemical and Biophysical Research Communications, 528 (2), 285-291, 2020. (https://doi.org/10.1016/j.bbrc.2020.05.074

Schipani R, Scheurer S, Florentin R, Critchley SE, Kelly DJ. Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites. Biofabrication. 12;12(3):035011, 2020. (https://doi.org/10.1088/1758-5090/ab8708

Freeman, F.E., Brennan, M.Á., Browe, D.C., Kelly, D.J. McNamara, L.M., Layrolle, P.A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect. Frontiers in Bioengineering and Biotechnology 8,230, 2020. (https://doi.org/10.3389/fbioe.2020.00230

Westin, C.B., Nagahara, M.H.T., Decarli, M.C., Kelly, D.J., Moraes, Â.M. Development and characterization of carbohydrate-based thermosensitive hydrogels for cartilage tissue engineering. European Polymer Journal, 129,109637, 2020. (https://doi.org/10.3390%2Fpolym13234199

Olwyn R Mahon, David C Browe, Tomas Gonzalez-Fernandez, Pierluca Pitacco, Ian T Whelan, Stanislas Von Euw, Christopher Hobbs, Valeria Nicolosi, Kyle T Cunningham, Kingston HG Mills, Daniel J Kelly, Aisling Dunne. Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner. Biomaterials 239, 119833, 2020. R Schipani, D Nolan, C Lally, DJ Kelly. Integrating Finite Element Modelling and 3D Printing to Engineer Biomimetic Polymeric Scaffolds for Tissue Engineering. Connective Tissue Research 61(2):174-189, 2020. (https://doi.org/10.1080/03008207.2019.1656720)

R Schipani, D Nolan, C Lally, DJ Kelly. Integrating Finite Element Modelling and 3D Printing to Engineer Biomimetic Polymeric Scaffolds for Tissue Engineering. Connective Tissue Research 61(2):174-189, 2020. (https://doi.org/10.1080/03008207.2019.1656720)

2019:

F Freeman, D Browe, J Nulty, S Von Euw, W Grayson, DJ Kelly. Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering. e Cells and Materials, 38, 168-187, 2019. (https://doi.org/10.22203/ecm.v038a12

AM McDermott, S Herberg, DE Mason, JM Collins, HB Pearson, JH Dawahare, R Tang, AN Patwa, MW Grinstaff, DJ Kelly, E Alsberg, JD Boerckel. Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration. Science translational medicine 11 (495), eaav7756, 2019. (https://doi.org/10.1126/scitranslmed.aav7756)

 OR Mahon, DJ Kelly, GM McCarthy, A Dunne. Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization. Osteoarthritis and cartilage (in press). (https://doi.org/10.1016/j.joca.2019.10.010

EJ Sheehy, DJ Kelly, FJ O’Brien. Biomaterial-based endochondral bone regeneration: A shift from traditional tissue engineering paradigms to developmentally inspired strategies. Materials Today Bio, 100009, 2019. (https://doi.org/10.1016/j.mtbio.2019.100009

DC Browe, OR Mahon, PJ Díaz‐Payno, N Cassidy, I Dudurych, A Dunne, DJ Kelly. Glyoxal cross‐linking of solubilised extracellular matrix to produce highly porous, elastic and chondro‐permissive scaffolds for orthopaedic tissue engineering. Journal of Biomedical Materials Research Part A, 107(10):2222-2234, 2019. (https://doi.org/10.1002/jbm.a.36731

Gonzalez-Fernandez T., Rathan S., Hobbs C., Pitacco P., Freeman F.E., Cunniffe G.M., Dunne N.J., McCarthy H., Nicolosi V., O’Brien F.J., Kelly D.J Pore-Forming Bioinks to Enable Spatio-Temporally Defined Gene Delivery in Bioprinted Tissues. Journal of Controlled Release 301, 13-27, 2019. (https://doi.org/10.1016/j.jconrel.2019.03.006

Sridharan, R., Cavanagh, B., Cameron, A., Kelly, D.J. O’Brien, F.J. Material stiffness influences the polarization state, function and migration of macrophages. Acta Biomaterilia 15;89:47-59, 2019. (https://doi.org/10.1016/j.actbio.2019.02.048

Olvera, D., Schipani, R., Sathy, B., Kelly, D.J. Electrospinning of highly porous yet mechanically functional microfibrillar scaffolds at the human scale for ligament and tendon tissue engineering. Biomedical Materials 14 (3), 035016, 2019. (https://doi.org/10.1088/1748-605x/ab0de1

Sathy, B.N., Daly, A., Olvera, D., Fernandez, T.G., Cunniffe, G., Pentlavalli, S., Chambers, P., Dunne, N. McCarthy, H.O., Jeon, O., Alsberg, E., Donahue, T.H., Kelly, D.J. Hypoxia Mimicking Hydrogels to Regulate the Fate of Transplanted Stem Cells. Acta Biomaterilia 88, 314-324, 2019. (https://doi.org/10.1016/j.actbio.2019.02.042

Daly, A., Kelly, D.J. Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers. Biomaterials 197, 194-206, 2019. (https://doi.org/10.1016/j.biomaterials.2018.12.028

Rathan, S., Dejob, L., Schipani, R., Haffner, B., Möbius, M.E., Kelly, D.J Fiber Reinforced Cartilage ECM Functionalized Bioinks for Functional Cartilage Tissue Engineering. Advanced Healthcare Materials 8 (7), 1801501, 2019. (https://doi.org/10.1002/adhm.201801501)  

Pauly, H., Kelly, D.J., Popat, K., Palmer, R., Haut Donahue, T.L Mechanical properties of a hierarchical electrospun scaffold for ovine anterior cruciate ligament replacement. Journal of Orthopaedic Research 37 (2), 421-430, 2019. (https://doi.org/10.1002/jor.24183

Sridharan, R., Ryan, E.J., Kearney, C.J., Kelly, D.J., O’Brien, F.J. Macrophage Polarization in Response to Collagen Scaffold Stiffness Is Dependent on Cross-Linking Agent Used To Modulate the Stiffness. ACS Biomater. Sci. Eng. 5 (2), 544-552, 2018. (https://doi.org/10.1021/acsbiomaterials.8b00910

Cunniffe, G.M., Díaz-Payno, P.J. Sheehy, E.J. Critchley, S.E., Almeida, H.V., Pitacco, P., Simon F. Carroll, S.F., Mahon, O.R., Dunne, A., Levingstone, T.J., Moran, C.J., Brady, R.T., O’Brien, F.J., Brama, P., Kelly, D.J. Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues. Biomaterials 188, 63-73, 2019. (https://doi.org/10.1016%2Fj.mtbio.2022.100343

Critchley, S., Cunniffe, G.M., O’Reilly, A., Diaz-Payno, P.J., Schipani, R., McAlinden, A., Withers, D., Shin, J.Y., Alsberg, E., Kelly, D.J Regeneration of osteochondral defects using developmentally inspired cartilaginous templates. Tissue Engineering Part A 25 (3-4), 159-171, 2019. (https://doi.org/10.1089/ten.tea.2018.0046)